Symmetrical polyarthritis is not always rheumatoid.

Symmetrical polyarthritis is not always rheumatoid.

Ulnar deviation is not always rheumatoid.

Investigating symmetrical polyarthritis of recent origin.

was self limiting in 40-50% of cases. Polyarticular onset and small joint involvement (box) consistently predicted an unfavourable outcome. Full blood count, erythrocyte sedimentation rate, C reactive protein, and anticyclic citrullinated peptide (anti-CCP) (or rheumatoid factor) help in confirming a diagnosis of rheumatoid arthritis and indicating the likely prognosis. Other antibodies such as...

Small is not always beautiful

Peer-to-peer content distribution systems have been enjoying great popularity, and are now gaining momentum as a means of disseminating video streams over the Internet. In many of these protocols, including the popular BitTorrent, content is split into mostly fixed-size pieces, allowing a client to download data from many peers simultaneously. This makes piece size potentially critical for perf...

Promiscuity is not always bad.

In the recent issue of Cell, Bonham et al. (2014) reveal that the sorting adaptor TIRAP regulates the assembly of the Myddosome upon Toll-like receptor activation from both the cell surface and endosomes through its promiscuous binding to lipids.